Conceptualizing Overdiagnosis in Cancer Screening

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Conceptualizing overdiagnosis in cancer screening.

The aim of cancer screening is to detect asymptomatic cancers whose treatment will result in extension of life, relative to length of life absent screening. Unfortunately, cancer screening also results in overdiagnosis, the detection of cancers that, in the absence of screening, would not present symptomatically during one's lifetime. Thus, their detection and subsequent treatment is unnecessar...

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Estimation of Overdiagnosis in Breast Cancer Screening

I. Summary The benefit of breast cancer (BC) screening with mammography has been demonstrated by randomized controlled trials (RCTs). However, there is a growing concern about the harms of screening, in particular the problem of overdiagnosis. It occurs when screening detects a breast cancer that would not have presented clinically in the woman's lifetime in the absence of screening. Overdiagno...

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Overestimating Overdiagnosis in Breast Cancer Screening

Overdiagnosis in breast cancer has been a focus of increasing concern with wide ranges of calculations made indirectly through the study of prospective randomized trials and analyses of large registries. While most admit that some degree of overdiagnosis is inherent with ductal carcinoma in situ (DCIS), the rate of overdiagnosis with invasive disease is highly controversial. Although it is gene...

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Overdiagnosis of gastric cancer by endoscopic screening

Gastric cancer screening using endoscopy has recently spread in Eastern Asian countries showing increasing evidence of its effectiveness. However, despite the benefits of endoscopic screening for gastric cancer, its major harms include infection, complications, false-negative results, false-positive results, and overdiagnosis. The most serious harm of endoscopic screening is overdiagnosis and t...

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Responses to Overdiagnosis in Thyroid Cancer Screening among Korean Women

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ژورنال

عنوان ژورنال: JNCI Journal of the National Cancer Institute

سال: 2015

ISSN: 0027-8874,1460-2105

DOI: 10.1093/jnci/djv014